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  "Description": "T (extent of the primary tumor), N (absence or presence\nand extent of regional lymph node metastasis) and M (absence or\npresence of distant metastasis) are three components to\ndescribe the anatomical tumor extent. TNM stage is important in\ntreatment decision-making and outcome predicting. The existing\noropharyngeal Cancer (OPC) TNM stages have not made distinction\nof the two sub sites of Human papillomavirus positive (HPV+)\nand Human papillomavirus negative (HPV-) diseases. We developed\nnovel criteria to assess performance of the TNM stage grouping\nschemes based on parametric modeling adjusting on important\nclinical factors. These criteria evaluate the TNM stage\ngrouping scheme in five different measures: hazard consistency,\nhazard discrimination, explained variation, likelihood\ndifference, and balance. The methods are described in Xu, W.,\net al. (2015)\n<https://www.austinpublishinggroup.com/biometrics/fulltext/biometrics-v2-id1014.php>.",
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